Pascal Greggory started his acting career in the mid-1970s, first on stage then on screen, after attending the Jean Périmony drama school and the National Drama School in Paris (Conservatoire de Paris), the latter as an unregistered student. He was offered his first major role in 1979 as Branwell Brontë in the film The Brontë Sisters directed by André Téchiné. In 1983, he was cast as one of the main characters in Pauline à la plage by Eric Rohmer, although he then decided to dedicate himself to the theatre.
From the 1990s, Pascal Greggory’s film career took on a new lease of life with parts in Eric Rohmer’s L’Arbre, le Maire et la Médiathèque or Patrice Chéreau’s La Reine Margot. From then on, he played many leading roles on screen while still busy on stage. He notably received great critical acclaim for his performance in Patrice Chéreau’s production of the play Dans la solitude des champs de coton by Bernard-Marie Koltès.
In 1999, he was named ‘étoile d’or’ (golden star) as male revelation of the year and received the César for best actor for his part in the film Ceux qui m’aiment prendront le train. He was awarded another César for best actor in 2001 for his part in La Confusion des genres as well as a César for best supporting actor in La Môme (2008).